5-HT3 subunit A

Click on sections of picture to learn more about research on individual amino acids. Numbering of the 5-HT3 subunit A sequence starts at the beginning of the mature protein. Only amino acids in the mature protein are shown.

amino acid all M2-M3 Linker M1 M1-M2 Linker M2 N-Terminus M3 M3-M4 Linker M4

5-HT3A - GENBANK

5-HT3A - FASTA

5-HT3A - Alignment

5-HT3A L (mouse) - GENBANK

5-HT3A L (mouse) - FASTA

5-HT3A L (mouse) - Alignment

5-HT3A splice variant --- Publications

 

 

 

 


 

 

 

 

N-Terminus

Arg 24 Arg 25 Ser 26 Arg 27 Asn 28 Thr 29 Thr 30 Arg 31 Pro 32 Ala 33 Leu 34 Leu 35 Arg 36 Leu 37 Ser 38 Asp 39 Tyr 40 Leu 41 Leu 42 Thr 43 Asn 44 Tyr 45 Arg 46 Lys 47 Glu 48 Val 49 Arg 50 Pro 51 Val 52 Arg 53 Asp 54 Trp 55 Arg 56 Lys 57 Pro 58 Thr 59 Thr 60 Val 61 Ser 62 Ile 63 Asp 64 Val 65 Ile 66 Val 67 Tyr 68 Ala 69 Ile 70 Leu 71 Asn 72 Val 73 Asp 74 Glu 75 Lys 76 Asn 77 Gln 78 Val 79 Leu 80 Thr 81 Thr 82 Tyr 83 Ile 84 Trp 85 Tyr 86 Arg 87 Gln 88 Tyr 89 Trp 90 Thr 91 Asp 92 Glu 93 Phe 94 Lys 95 Gln 96 Trp 97 Asn 98 Pro 99 Glu 100 Asp 101 Phe 102 Asp 103 Asn 104 Ile 105 Thr 106 Lys 107 Leu 108 Ser 109 Ile 110 Pro 111 Thr 112 Asp 113 Ser 114 Ile 115 Trp 116 Val 117 Pro 118 Asp 119 Ile 120 Leu 121 Ile 122 Asn 123 Glu 124 Phe 125 Val 126 Asp 127 Val 128 Gly 129 Lys 130 Ser 131 Pro 132 Asn 133 Ile 134 Pro 135 Tyr 136 Val 137 Tyr 138 Ile 139 Arg 140 His 141 Gln 142 Gly 143 Glu 144 Val 145 Gln 146 Asn 147 Tyr 148 Lys 149 Pro 150 Leu 151 Gln 152 Val 153 Val 154 Thr 155 Ala 156 Cys 157 Ser 158 Leu 159 Asp 160 Ile 161 Tyr 162 Asn 163 Phe 164 Pro 165 Phe 166 Asp 167 Val 168 Gln 169 Asn 170 Cys 171 Ser 172 Leu 173 Thr 174 Phe 175 Thr 176 Ser 177 Trp 178 Leu 179 His 180 Thr 181 Ile 182 Gln 183 Asp 184 Ile 185 Asn 186 Ile 187 Ser 188 Leu 189 Trp 190 Arg 191 Leu 192 Pro 193 Glu 194 Lys 195 Val 196 Lys 197 Ser 198 Asp 199 Arg 200 Ser 201 Val 202 Phe 203 Met 204 Asn 205 Gln 206 Gly 207 Glu 208 Trp 209 Glu 210 Leu 211 Leu 212 Gly 213 Val 214 Leu 215 Pro 216 Tyr 217 Phe 218 Arg 219 Glu 220 Phe 221 Ser 222 Met 223 Glu 224 Ser 225 Ser 226 Asn 227 Tyr 228 Tyr 229 Ala 230 Glu 231 Met 232 Lys 233 Phe 234 Tyr 235 Val 236 Val 237 Ile 238 Arg 239 Arg 240 Arg 241 Pro 242
Residues with mutations: [ Tyr 45 ][ Pro 51 ] [ Trp 55 ] [ Ile 66 ] [ Tyr 68 ] [ Thr 81 ] [ Thr 82 ] [ Tyr 83 ] [ Ile 84 ] [ Trp 85 ] [ Tyr 86 ] [ Arg 87 ] [ Gln 88 ] [ Tyr 89 ] [ Trp 90 ] [ Glu 93 ] [ Trp 97 ] [ Pro 99 ] [ Phe 102 ] [ Trp 116 ] [ Pro 118 ] [ Asn 123 ] [ Glu 124 ] [ Tyr 136 ][ Tyr 138 ] [ Tyr 148 ] [ Tyr 162 ][ Phe 164 ] [ Pro 165 ] [ Phe 166 ] [ Thr 174 ] [ Thr 176 ] [ Ser 177 ][ Trp 178 ] [ Leu 179 ] [ Trp 190 ] [ Val 196 ] [ Lys 197 ][ Ser 198 ] [ Ser 201 ] [ Val 202 ][Trp 209 ] [ Leu 215 ] [ Pro 216 ][ Tyr 217 ] [ Arg 219 ] [ Glu 220 ] [ Phe 221 ][ Met 223 ] [ Glu 224 ] [ Ser 225 ] [ Tyr 228 ] [ Tyr 229 ][ Glu 231 ] [ Lys 233 ] [ Tyr 235 ][ Val 237 ][ Arg 241 ]

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M1

Leu 243 Phe 244 Tyr 245 Val 246 Val 247 Ser 248 Leu 249 Leu 250 Leu 251 Pro 252 Ser 253 Ile 254 Phe 255 Leu 256 Met 257 Val 258 Met 259 Asp 260 Ile 261 Val 262 Gly 263 Phe 264 Tyr 265

Residues with Mutations: [ Ser 248 ][ Pro 252 ]

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M1-M2 Linker

Leu 266 Pro 267 Pro 268 Asn 269 Ser 270 Glu 272 Gly 271 Arg 273

Residues with Mutations: [ Asn 269 ] [ Ser 270 ] [ Gly 271 ] [ Glu 272 ] [ Arg 273 ]

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M2

Val 286 Val 274 Ser 275 Phe 276 Lys 277 Ile 278 Thr 279 Leu 280 Leu 281 Leu 282 Gly 283 Tyr 284 Ser 285 Val 286 Phe 287 Leu 288 Ile 289 Ile 290 Val 291 Ser 292

Residues with Mutations: [ Val 274 ] [ Ser 275 ] [ Phe 276 ] [ Lys 277 ] [ Ile 278 ] [ Thr 279 ] [ Leu 280 ] [ Leu 281 ] [ Leu 282 ] [ Gly 283 ] [ Tyr 284 ] [ Ser 285 ] [ Val 286 ] [ Phe 287 ] [ Leu 288 ] [ Ile 289 ] [ Ile 290 ] [ Val 291 ] [ Ser 292 ]

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M2-M3 Linker

Asp 293 Thr 294 Leu 295 Pro 296 Ala 297 Thr 298 Ala 299 Ile 300 Gly 301 Thr 302  

Residues with Mutations: [ Asp 293 ] [ Pro 296 ] [ Ala 297 ]

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M3

Pro 303 Leu 304 Ile 305 Gly 306 Val 307 Tyr 308 Phe 309 Val 310 Val 311 Cys 312 Met 313 Ala 314 Leu 315 Leu 316 Val 317 Ile 318 Ser 319 Leu 320 Ala 321

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M3-M4 Linker

Glu 322 Thr 323 Ile 324 Phe 325 Ile 326 Val 327 Arg 328 Leu 329 Val 330 His 331 Lys 332 Gln 333 Asp 334 Leu 335 Gln 336 Gln 337 Pro 338 Val 339 Pro 340 Ala 341 Trp 342 Leu 343 Arg 344 His 345 Leu 346 Val 347 Leu 348 Glu 349 Arg 350 Ile 351 Ala 352 Trp 353 Leu 354 Leu 355 Cys 356 Leu 357 Arg 358 Glu 359 Gln 360 Ser 361 Thr 362 Ser 363 Gln 364 Arg 365 Pro 366 Pro 367 Ala 368 Thr 369 Ser 370 Gln 371 Ala 372 Thr 373 Lys 374 Thr 375 Asp 376 Asp 377 Cys 378 Ser 379 Ala 380 Met 381 Gly 382 Asn 383 His 384 Cys 385 Ser 386 His 387 Met 388 Gly 389 Gly 390 Pro 391 Gln 392 Asp 393 Phe 394 Glu 395 Lys 396 Ser 397 Pro 398 Arg 399 Asp 400 Arg 401 Cys 402 Ser 403 Pro 404 Pro 405 Pro 406 Pro 407 Pro 408 Arg 409 Glu 410 Ala 411 Ser 412 Lys 413 Ala 414 Val 415 Cys 416 Gly 417 Leu 418 Leu 419 Gln 420 Glu 421 Leu 422 Ser 423 Ser 424 Ile 425 Arg 426 Gln 427 Phe 428 Leu 429 Glu 430 Lys 431 Arg 432 Asp 433 Glu 434 Ile 435 Arg 436 Glu 437 Val 438 Ala 439 Arg 440 Asp 441 Trp 442 Leu 443 Arg 444 Val 445 Gly 446 Ser 447 Val 448 Leu 449 Asp 450 Lys 451 Leu 452 Leu 453 Phe 454 His 455
Residues with Mutations: [ Thr 323 ] [ Arg 344 ][ Thr 369 ][ Thr 375 ][ Ser 379 ] [ Ser 386 ] [ Pro 391 ][ Ser 397 ][ Ser 403 ][ Ser 412 ][ Ser 423 ][ Ser 424 ][ Arg 426 ] [ Arg 432 ] [ Arg 436 ] [ Arg 440 ][ Ser 447 ]

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M4

Ile 456 Tyr 457 Leu 458 Leu 459 Ala 460 Val 461 Leu 462 Ala 463 Tyr 464 Ser 465 Ile 466 Thr 467 Leu 468 Val 469 Met 470 Leu 471 Trp 472 Ser 473 Ile 474 Trp 475 Gln 476 Tyr 477 Ala 478

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Alignment