Human nACh a4 -- Cys 227

Species Original Mutated to Mutation
Human Cys 227 Phe

C227F
Rat Equivalent Asn 232    
Mouse Equivalent Asn 232    

hCys227Phe

Rush R, Kuryatov A, Nelson ME, Lindstrom J. First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine. Mol Pharmacol. 2002 Jun;61(6):1416-22.

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