nACh subunit a5

Click on sections of the picture to learn more about research on individual amino acids. Numbering of the nACh a5 subunit sequences start at the beginning of the signal sequence. Only amino acids in the mature protein are shown.

amino acid all M4 M3-M4 Linker M3 M2-M3 Linker M2 M1-M2 Linker N-Terminus M1

nACh a5 -- GENBANK

nACh a5 -- FASTA

nACh a5 -- Alignment

 

 

 

 

 

 

 

 

 

 

N-Terminus

Ala 23 Leu 24 Arg 25 Ser 26 Ser 27 Arg 28 Ala 29 Arg 30 Arg 31 Ala 32 Ala 33 Arg 34 Arg 35 Gly 36 Leu 37 Ser 38 Glu 39 Pro 40 Ser 41 Ser 42 Ile 43 Ala 44 Lys 45 His 46 Glu 47 Asp 48 Ser 49 Leu 50 Leu 51 Lys 52 Asp 53 Pro 250 Leu 249 Arg 248 Lys 247 Leu 54 Phe 55 Gln 56 Asp 57 Tyr 58 Glu 59 Arg 60 Trp 61 Val 62 Arg 63 Pro 64 Val 65 Glu 66 His 67 Leu 68 Asn 69 Asp 70 Lys 71 Ile 72 Lys 73 Ile 74 Lys 75 Phe 76 Gly 77 Leu 78 Ala 79 Ile 80 Ser 81 Gln 82 Leu 83 Val 84 Asp 85 Val 86 Asp 87 Glu 88 Lys 89 Asn 90 Gln 91 Leu 92 Met 93 Thr 94 Thr 95 Asn 96 Val 97 Trp 98 Leu 99 Lys 100 Gln 101 Glu 102 Trp 103 Thr 104 Asp 105 Val 106 Lys 107 Leu 108 Arg 109 Trp 110 Asn 111 Pro 112 Asp 113 Asp 114 Tyr 115 Gly 116 Gly 117 Ile 118 Lys 119 Val 120 Ile 121 Arg 122 Val 123 Pro 124 Ser 125 Asp 126 Ser 127 Val 128 Trp 129 Thr 130 Pro 131 Asp 132 Ile 133 Val 134 Leu 135 Phe 136 Asp 137 Asn 138 Ala 139 Asp 140 Gly 141 Arg 142 Phe 143 Glu 144 Gly 145 Thr 146 Ser 147 Thr 148 Lys 149 Thr 150 Val 151 Ile 152 Arg 153 Tyr 154 Asn 155 Gly 156 Thr 157 Val 158 Thr 159 Trp 160 Thr 161 Pro 162 Pro 163 Ala 164 Asn 165 Tyr 166 Lys 167 Ser 168 Ser 169 Cys 170 Thr 171 Ile 172 Asp 173 Val 174 Thr 175 Phe 176 Phe 177 Pro 178 Phe 179 Asp 180 Leu 181 Gln 182 Asn 183 Cys 184 Ser 185 Met 186 Lys 187 Phe 188 Gly 189 Ser 190 Trp 191 Thr 192 Tyr 193 Asp 194 Gly 195 Ser 196 Gln 197 Val 198 Asp 199 Ile 200 Ile 201 Leu 202 Glu 203 Asp 204 Gln 205 Asp 206 Val 207 Asp 208 Arg 209 Lys 210 Asp 211 Phe 212 Phe 213 Asp 214 Asn 215 Gly 216 Glu 217 Trp 218 Glu 219 Ile 220 Val 221 Ser 222 Ala 223 Thr 224 Gly 225 Ser 226 Lys 227 Gly 228 Asn 229 Arg 230 Thr 231 Asp 232 Ser 233 Cys 234 Cys 235 Trp 236 Tyr 237 Pro 238 Tyr 239 Val 240 Thr 241 Tyr 242 Ser 243 Phe 244 Val 245 Ile 246

Residues with mutations: [ ]

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M1

Pro 275 Leu 274 Tyr 273 Val 271 Leu 270 Phe 272 Leu 267 Thr 268 Val 269 Phe 266 Ser 265 Leu 264 Gly 263 Ile 262 Cys 261 Pro 260 Ile 259 Ile 258 Leu 257 Phe 256 Leu 255 Thr 254 Tyr 253 Phe 252 Leu 251

Residues with mutations: [ ]

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M1-M2 Linker

Ser 276 Asp 277 Glu 278 Gly 279 Glu 280 Lys 281 Residues with mutations: [ ]

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M2

Ile 282 Cys 283 Pro 304 Ile 303 Leu 284 Cys 285 Thr 286 Ser 287 Val 288 Leu 289 Val 290 Ser 291 Leu 292 Thr 293 Val 294 Phe 295 Leu 296 Leu 297 Val 298 Ile 299 Glu 300 Glu 301 Ile 302

Residues with mutations: [Val 290]

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M2-M3 Linker

Ser 305 Ser 306 Ser 307 Lys 308 Val 309
Residues with mutations: [ ]

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M3

Ile 310 Pro 311 Leu 312 Ile 335 Ala 334 Phe 333 Val 332 Ile 313 Gly 314 Glu 315 Tyr 316 Leu 317 Val 318 Phe 319 Thr 320 Met 321 Ile 322 Phe 323 Val 324 Thr 325 Leu 326 Ser 327 Ile 328 Met 329 Val 330 Thr 331

Residues with mutations: [ ]

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M3-M4 Linker

Asn 336 Lys 421 Trp 420 Asp 419 Glu 418 Val 417 Val 416 Glu 415 Arg 414 Val 413 Asp 412 Asn 411 Glu 410 His 409 Arg 408 Lys 407 His 406 Arg 405 Thr 404 Ile 403 Tyr 402 Arg 401 Ile 400 Ser 399 Asp 398 Leu 397 Ala 396 Ala 395 Glu 394 Leu 393 Thr 392 Asn 391 Arg 390 Ser 389 Ser 388 Lys 387 Pro 386 Gly 385 Ser 384 Gly 383 Ser 382 Glu 381 Thr 380 Glu 379 Glu 378 Lys 377 Gln 376 Thr 375 Phe 374 Tyr 373 Arg 372 Asp 371 Val 370 His 369 Ser 368 Arg 367 Met 366 Cys 365 Leu 364 Leu 363 Lys 362 Pro 361 Leu 360 Thr 359 His 358 Leu 357 Phe 356 Ile 355 Lys 354 Arg 353 Val 352 Leu 351 Pro 350 Ala 349 Met 348 Ala 347 Asn 346 His 345 Thr 344 Ser 343 Ser 342 Ser 341 Arg 340 His 339 His 338 Ile 337
Residues with mutations: [ ]

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M4

Lys 468 Asn 467 Ala 466 Asn 465 Gly 464 Ile 463 His 462 Val 461 Pro 460 Phe 422 Ile 423 Ala 424 Gln 425 Val 426 Leu 427 Asp 428 Arg 429 Met 430 Phe 431 Leu 432 Trp 433 Thr 434 Phe 435 Leu 436 Phe 437 Val 438 Ser 439 Ile 440 Val 441 Gly 442 Ser 443 Leu 444 Gly 445 Leu 446 Phe 447 Val 448 Pro 449 Val 450 Ile 451 Tyr 452 Lys 453 Trp 454 Ala 455 Asn 456 Ile 457 Leu 458 Ile 459

Residues with mutations: [ ]

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Alignment

Home Page N-Terminus First Membrane Spanning Second Membrane Spanning Third Membrane Spanning Outside the Cell Inside the Cell C-Terminus