nACh subunit e

Click on sections of picture to learn more about research on individual amino acids. Numbering of the nACh e subunit sequences start at the beginning of the mature protein. Only amino acids in the mature protein are shown.

amino acid all N-Terminus M1 M1-M2 Linker M2 M2-M3 Linker M3 M3-M4 Linker M4

nACh e -- GENBANK

nACh e -- FASTA

nACh e -- Alignment

 

 

 

 

 

 

 

 

 

N-Terminus

Residues with mutations: [ Pro 121 ] [ Cys 128 ] [ Val 132 ] [ Ser 143 ] [ Asp 175 ] [ Asn 182 ] Lys 1 Asn 2 Glu 3 Glu 4 Leu 5 Arg 6 Leu 7 Tyr 8 His 9 His 10 Leu 11 Phe 12 Asn 13 Asn 14 Tyr 15 Asp 16 Pro 17 Gly 18 Ser 19 Arg 20 Pro 21 Val 22 Arg 23 Glu 24 Pro 25 Glu 26 Asp 27 Thr 28 Val 29 Thr 30 Ile 31 Ser 32 Leu 33 Lys 34 Val 35 Thr 36 Leu 37 Thr 38 Asn 39 Leu 40 Ile 41 Ser 42 Leu 43 Asn 44 Glu 45 Lys 46 Glu 47 Glu 48 Thr 49 Leu 50 Thr 51 Thr 52 Ser 53 Val 54 Trp 55 Ile 56 Gly 57 Ile 58 Asp 59 Trp 60 Gln 61 Asp 62 Tyr 63 Arg 64 Leu 65 Asn 66 Tyr 67 Ser 68 Lys 69 Asp 70 Asp 71 Phe 72 Gly 73 Gly 74 Ile 75 Glu 76 Thr 77 Leu 78 Arg 79 Val 80 Pro 81 Ser 82 Leu 83 Glu 84 Val 85 Trp 86 Leu 87 Pro 88 Glu 89 Ile 90 Val 91 Leu 92 Glu 93 Asn 94 Asn 95 Ile 96 Asp 97 Gly 98 Gln 99 Phe 100 Gly 101 Val 102 Ala 103 Tyr 104 Asp 105 Ala 106 Asn 107 Val 108 Leu 109 Val 110 Tyr 111 Glu 112 Gly 113 Gly 114 Ser 115 Val 116 Thr 117 Trp 118 Leu 119 Pro 120 Pro 121 Ala 122 Ile 123 Tyr 124 Arg 125 Ser 126 Val 127 Cys 128 Ala 129 Val 130 Glu 131 Val 132 Thr 133 Tyr 134 Phe 135 Pro 136 Phe 137 Asp 138 Trp 139 Gln 140 Asn 141 Cys 142 Ser 143 Leu 144 Ile 145 Phe 146 Arg 147 Ser 148 Gln 149 Thr 150 Tyr 151 Asn 152 Ala 153 Glu 154 Glu 155 Val 156 Glu 157 Phe 158 Thr 159 Phe 160 Ala 161 Val 162 Asp 163 Asn 164 Asp 165 Gly 166 Lys 167 Thr 168 Ile 169 Asn 170 Lys 171 Ile 172 Asp 173 Ile 174 Asp 175 Thr 176 Glu 177 Ala 178 Tyr 179 Thr 180 Glu 181 Asn 182 Gly 183 Glu 184 Trp 185 Ala 186 Ile 187 Asp 188 Phe 189 Cys 190 Pro 191 Gly 192 Val 193 Ile 194 Arg 195 Arg 196 His 197 His 198 Gly 199 Gly 200 Ala 201 Thr 202 Asp 203 Gly 204 Pro 205 Gly 206 Glu 207 Tjr 208 Asp 209 Val 210 Ile 211 Tyr 212 Ser 213 Leu 214 Ile 215 Ile 216 Arg 217 Arg 218 Lys 219 Pro 220

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M1

Phe 243 Tyr 242 Ala 241 Leu 240 Leu 239 Val 238 Leu 237 Gly 236 Ser 235 Ile 234 Leu 233 Val 232 Cys 231 Pro 230 Val 229 Ile 228 Ile 227 Asn 226 Ile 225 Val 224 Tyr 223 Phe 222 Leu 221

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M1-M2 Linker

Leu 244 Pro 245 Ala 246 Gln 247 Ala 248 Gly 249 Gly 250 Gln 251 Lys 252

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M2

Cys 253 Thr 254 Val 255 Ser 256 Ile 257 Asn 258 Val 259 Leu 260 Leu 261 Ala 262 Gln 263 Thr 264 Val 265 Phe 266 Leu 267 Phe 268 Leu 269 Ile 270 Ala 271

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M2-M3 Linker

Gln 272 Lys 276 Ile 274 Pro 275 Glu 276 Thr 277 Ser 278 Leu 279 Ser 280 Val 281

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M3

Pro 282 Leu 283 Ile 284 Gly 285 Arg 286 Phe 287 Leu 288 Ile 289 Phe 290 Val 291 Met 292 Val 293 Val 294 Ala 295 Thr 296 Leu 297 Ile 298 Val 299 Met 300

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M3-M4 Linker

Trp 440 Phe 439 Cys 438 Ile 437 Asn 436 Asp 435 Leu 434 Ala 433 Asn 432 Gly 431 Met 430 Arg 429 Val 428 Trp 427 Asp 426 Ser 425 Val 424 Glu 423 Glu 422 Gly 421 Thr 420 Ala 419 Glu 418 Gln 417 Asp 416 Arg 415 Thr 414 Ser 413 Glu 412 Ala 411 Val 410 Phe 409 Asn 408 Val 407 Ala 406 Asp 405 Val 404 Cys 403 Cys 402 Arg 401 Val 400 Glu 399 Pro 398 Ala 397 Ala 396 Ala 395 Gly 394 Leu 393 Ser 392 Gln 391 Cys 390 Phe 389 Ala 388 Ala 387 Thr 386 Trp 385 Thr 384 Gly 383 Gln 382 Arg 381 His 380 Arg 379 Gln 378 Gly 377 Glu 376 Phe 375 Val 374 Leu 373 Glu 372 Ser 371 Arg 370 Pro 369 Lys 368 Lys 367 Leu 366 Ile 365 Leu 364 Glu 363 Glu 362 Ala 361 Arg 360 Leu 359 Leu 358 Leu 357 Gly 356 Val 355 Ser 354 Ser 353 Ala 352 Arg 351 Arg 350 Pro 349 Pro 348 Ser 347 Ala 346 Ala 345 Arg 344 Pro 343 Ala 342 Glu 341 Pro 340 Pro 339 Pro 338 Pro 337 Ser 336 Gly 335 Leu 334 Leu 333 Arg 332 Pro 331 Leu 330 Leu 329 Glu 328 Leu 327 Leu 326 Val 325 His 324 Arg 323 Leu 322 Arg 321 Pro 320 Ser 319 Met 318 Ala 317 His 316 Thr 315 Thr 314 Pro 313 Thr 312 Arg 311 Gln 310 Ser 309 Val 308 Asn 307 Leu 306 Val 305 Ile 304 Val 303 Cys 302 Asn 301

Residues with mutations: [ Ala 411 ]

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M4

Ala 441 Ala 442 Leu 443 Val 444 Leu 445 Phe 446 Ser 447 Val 448 Gly 449 Ser 450 Ser 451 Leu 452 Ile 453 Phe 454 Leu 455 Gly 456 Ala 457 Tyr 458 Phe 459 Asn 460 Arg 461 Val 462 Pro 463 Asp 464 Leu 465 Pro 466 Tyr 467 Ala 468 Pro 469 Cys 470 Ile 471 Gln 472 Pro 473

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Alignment

N-Terminus First Membrane Spanning Second Membrane Spanning Third Membrane Spanning Outside the Cell Inside the Cell C-Terminus